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What brand LapTop's are you using?
If you're able to enter the Laptop's BIOS, look for a setting regarding "Legacy USB Support" and enable that.
Another option is to run a loop back test in USB to Serial adapter and see if you get any errors.
Also, check the OS Event Logs and look for any errors that might relate to the Power to Win and/or USB. Look in the Application Log, System Log, and Security Log. In WinXP you can do this by right clicking "My Computer" and click on "Manage" from there select the Event Viewer in the list and pick select one of the above mentioned logs and look for any errors around the time you failed to communicate and/or plugged in the USB to Serial adapter.
Another thought, do you have the rear speaker magnet near the USB and/or RS232 cable? Have you tried tracing the RS232 cable back to the EFI unit and making sure all is good there?
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'07 Exige S (Track Pack & LSD) + EFi 550ci injectors + Mahle 9:1 + DRS Port + SuperTech Valves + Weapon R Header + 2.9" pully + TODA Clutch + FF Engine Damper + RLS IC + Greddy catch cans + opened roof slot + RTD brace + Milled steering arms + Larini 8" + FF air intake + Moroso oil pan + Ultradisc 2 piece front/rear + Reverie 1650mm wing + ReVerie front splitter + IQ3 Dash + 4pt ASM + Pioneer AVIC-N2 nav + rear camera + RAC monolites 888s 195/225 + Lotus LSS Hoosier R6 205/225 @ 1921 lbs
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