Your wife will probably like to explore Yorkville, a high-end shopping/dining area near Yonge and Bloor. For the kids there is the Ontario Science Centre (very hands-on), the Royal Ontario Museum (great dinosaur exhibit) and the CN Tower (you can see Niagara Falls on a clear day). The Toronto Zoo is pretty nice as well, but is a bit out of town. You can buy an all-day family pass ($10 Cdn) for the TTC which includes unlimited subway/bus and street car travel for a family of 4. The TTC is pretty well laid out and makes getting around town the easiest with no gridlock or parking hassles. PM me if you have any other questions about things to do in TO. Don't forget to visit Gentry Lane and ogle the Jim Clark special edition Elise SC!