In the FAQ thread (stickied at the top) I have pointed out some reasons why I think this car may be a bad choice for you.
Repeating what others have said...
1. It's a pain to get in and out. Sure, you can do it. But your body type, how limber you are, age, if you wear a dress, etc might put more emphasis on this. It's one of the hardest cars I know of to get in and out. Like climbing in a race car with a roll cage. Totally worth it to me, but for some people that is going to get tiresome.
2. Small. It's small.

That means you need to be on your toes. Now IMO, drivers should be on their toes anyway, because even if you are in a 4000 pound car, you are no invincible. But some people might not like *feeling* more vulnerable. I wuold counter that I can avoid accidents better, but that is me.
3. Small. You will be sitting very close to the passenger. If you are one that carpools to work, you may get tired of bumping elbows. It's like sitting in a coach airline seat. If I was a Real Estate agent taking clients, this would not be my daily driver.
4. Small. Hauling. lol. Not a good car for home depot runs. This limits the car's function. If you are on that throws in 4 suitcases for a weekend driving trip, this might be a problem. You will have to learn to pack light.
5. No spare tire. You have a can of fix-a-flat and a AAA card.
6. Small quality issues. There is no way a company like Lotus building this number of cars can have a team of design engineers working them to design the window switch and then millions of dollars of testing factilities to test that switch. Because of this, some things might be a little quirky. You have to live with that. If you want a car that never has issues...then you may not be happy with the Elise.
7. Ride quality. Some people may not be used to, or willing to live with, a rough ride. What might seem like a great road feel to one person, can be harsh kidney bruising to the next guy. This is no Cadillac.
8. Midengined. Not for everyone. If you have little driving skill and don't know your limitations... please do not get LSS.
9. A lot of your driving is in bad weather or snow. May not be your best choice.
10. Distance from service. If you live far away from your dealer or designated service person, this is going to be a hassle. It just is.
11. Not used to a small company that does not have a lot of people to handle the PR and such. We have heard complaints about the official web site, the cars not being at other shows, the lack of information from Lotus, etc. A lot of that is attributed to them being such a small company.
12. Attention. I had a friend that had a very cool car like this and sold it because it drew too much attention.